Regulation of phospholipid dynamics in brain

• Discussing how unwanted cells and comparts in living are removed. PtdSer is maintained to the inner side of membrane. exposed on cell surface. recognized by phagocytes for engulfment. exposure /recognition systems work brain. Phospholipids asymmetrically distributed at plasma Phosphatidylserine (PtdSer) exclusively located leaflet membrane while phosphatidylcholine (PtdCho) glycolipids mainly outer However, this asymmetry disrupted various physiological situations, In platelets, functions as a scaffold coagulation reaction, dead cells, serves an “Eat-me” signal efferocytosis. developing brain, synaptic connections over-formed during fetal period, but about half neurons removed apoptosis, dendritic compartments also phagocytes. During these processes, glial such microglia astrocyte engulf using several phagocytic receptors, recognizing direct binding or indirect way secreted molecules. Based recent findings, we will discuss eliminated neuronal circuit plasticity.